Gene and Allele

By default only PI, technician and scientist have the authority to add genes and alleles.

You should add gene and allele information before starting to add mouse records.

Click on the toolbar or menu Lab->Genes and Alleles to add new genes and alleles.

Add gene record first, then click "Edit Alleles" to add the alleles of the gene. The gene list is uneditable while editing the alleles. Click "Edit Genes" to go back to gene list.

"Chr" is the field for gene locus. It is important to know the genomic locus of genes that you paln to cross their mutants to make compound mutants.

The short names of a gene or allele will be shown in the genotype information of a mouse record on census. The length of gene shortname is best from 3-5 characters. Too short will decrease the specificity of search results by the gene. The length of allele shortname is best from 1-3 characters.

The suggested rules to name alleles are listed in the "gene" window and below:

Below are additional suggestions to name transgene and knockin:

The transgene is treated as a new gene even the coding region is the same as the gene already on the gene list. Below are some examples for Cre transgenes:

The genomic location is unknown for these Cre transgenes. Add an insertion allele (i) under these genes so the mice carrying the cre trangene will have genotype i/+ or i/i. For example, mice carrying Prx1cre will be shown as Prx1crei or Prx1crei/i (if homozygous) in the census.

Knockin is treated as an allele of the gene at the knockin locus. For example, cre knockin at Shh locus is an allele of Shh.

Any changes on the short name of genes or alleles will not be applied to the mouse records containing old names.